近日，一项针对健康中年人的大规模研究发现，MRI观察到的内脏脂肪和皮下脂肪越多，脑萎缩越严重，在女性中更为明显。
小作业：1. which types of fat did the study examine in relation to brain volume?
a) saturated and unsaturated fat.
b) visceral and subcutaneous fat.
c) brown and white fat.
d) trans and monounsaturated fat.
2. what did the researchers suggest as a potential intervention based on their findings?a) immediate surgical removal of abdominal fat.
b) ignoring abdominal fat as it has a minimal effect on brain volume.
c) targeting abdominal fat reduction to maintain brain health.
d) increasing abdominal fat in certain populations for better cognitive function.
原文不带注释：
abdominal fat linked to lower brain volume in midlife
from: medscape
new research provides strong evidence of an association between abdominal fat and reduced brain volumes, particularly those involved with cognitive function.
in large study of healthy middle-aged adults, greater visceral and subcutaneous abdominal fat on abdominal mri predicted brain atrophy on imaging, especially in women.
the study shows that excess fat is bad for the brain and worse in women, including in alzheimer's disease risk regions," lead author cyrus raji, md, phd, with the mallinckrodt institute of radiology, washington university, st. louis, missouri, told medscape medical news.
the study was published online august 28 in the journal aging and disease.
modifiable risk factor
multiple studies h**e suggested a connection between body fat accumulation and increased dementia risk. but few h**e examined the relationship between types of fat (visceral and subcutaneous) and brain volume.
for the new study, 10,000 healthy adults aged 20-80 years (mean age, 52.9 years; 53% men) underwent a short whole-body mri protocol. regression analyses of abdominal fat types and normalized brain volumes were evaluated, controlling for age and sex.
the research team found that higher amounts of both visceral and subcutaneous abdominal fat predicted lower total gray and white matter volume, as well as lower volume in the hippocampus, frontal cortex, and temporal, parietal, and occipital lobes.
the findings are quite dramatic," raji told medscape medical news. "overall, we found that both subcutaneous and visceral fat has similar levels of negative relationships with brain volumes."
women had a higher burden of brain atrophy with increased visceral fat than men. however, it's difficult to place the sex differences in context due to the lack of prior work specifically investigating visceral fat, brain volume loss, and sex differences, the researchers caution.
they also note that while statistically significant relationships were observed between visceral fat levels and gray matter volume changes, their effect sizes were generally small.
other limitations include the cross-sectional nature of the study, which precludes conclusions about causality. the analysis also did not account for other lifestyle factors such as physical activity, diet, and genetic variables.
the researchers call for further investigation "to better elucidate underlying mechanisms and discover possible interventions targeting abdominal fat reduction as a strategy to maintain brain health."
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带注释的全文：
abdominal fat linked to lower brain volume in midlife
from: medscape
new research provides strong evidence of an association between abdominal fat and reduced brain volumes, particularly those involved with cognitive function.
新的研究有力地证明了腹部脂肪与脑容量减少之间的关联，特别是在与认知功能相关的领域。
abdominal
abdominal b d m n l 的意思是“腹部的”，被解释为“腹部用于描述位于腹部或构成腹部一部分的东西”。”
volume
volume /ˈvɒl.ju m 1）的意思是“总计;”。总;Total“，英文解释是”一般事物的数量或数量”。